News Bulletin 18 February 2000

INDIA WILL EMERGE AS A STRONG PLAYER IN BIOTECHNOLOGY:Dr. P. K. Ghosh

India is expected to emerge as a strong player in the consumer market of biotechnology products in the coming years. By 2005 the comparative contributions of consumers from health care products are expected to rise to aboout 40% from the present 37%, while from agricultural products the rise would be from 28% to nearly 33%.

With appropriate help from the government it should be possible to attract sizable investment in this sector in the near future to create a local industry which is globally competitive. Wisdom lies in taking proactive steps within the provisions of the WTO and other international laws, to develop a competitive local industry and take advantage of the gearing consumer demand.

Over the next five years possibilities could be created for fresh investment of Rs. 7 to 8 billion in India that hold the promise of changing the biotech production scenario considerably. Such quantum of fresh investment if materialised, would hold the potential of providing a turnover of Rs. 9 to 10 billion during the next 5-7 years. That will contribute towards import substitution, augmentation of local production and introduction of some new products in the global market.

(Excerpts from the speech of Dr. P. K. Ghosh, Adviser, Department of Biotechnology at the panel discussion at Biotechnology India 2000 conference on 16 February 2000.)

BIOFIN LABORATORIES S. R. L. — pioneers in pharma technology

Biofin Laboratories was formed in 1986 in Norway with a joint venture between Norsk Bioferm and Biofin. The company undertook the development of several drugs among which Vitamin B12, Demethyclortetra-cycline, Xantan and Anti-tumour drugs are prominent.

The company has opened its laboratories in Iasi, Romania in 1994, and another company called Gazoldo degli Ippoliti in Italy in 1999.

The company provides all services necessary for the successful installation of technologies. Biofin offers transfer of technology for the production of antibiotics, semi-antibiotics, anticancer drugs, and biologicals. It offers process improvement in industrial strain supply, assistance in strain development program, supply of industrial fermentation procedures.

Biofin is engaged in engineering the design and upgradation of existing processes, large fermenter design, optimisation of production economics and process scale up from laboratory to full production scale.

KY-YEAST – Probiotic Feed Supplement

Experienced professional management backs up Kothari Fermentation and Biochem Ltd., incorporated in 1990. The company has set up "Yeast and its Derivatives" plant, based on latest technology at Secundrabad, in Uttar Pradesh.

The plant has an installed capacity to manufacture 8000 M. T. per annum of equivalent compressed yeast. The company is manufacturing fresh yeast, active dried yeast, instant dried yeast, inactive dried yeast, extracts & distillers yeast improver for food, feed, fermentation, pharmaceutical, vaccine & biotechnology industry.

KY–Yeast is productivity enhancer and probiotic feed supplement for monogastric and ruminant animals. KY Yeast is produced by fermentation of cane molasses. The yeast is dehydrated to make yeast cake. Fresh yeast cake is extruded and dried to reduce moisture employing specially designed fluid bed dryers. KY – Yeast is manufactured under hygienic, sterlised and clean environment to comply with acceptable fermentative quality and microbiological standards.

 

USE TISSUE CULTURE FOR INCREASING LAND PRODUCTIVITY: Dr.Vibha Dhawan

"India has pioneered a number of discoveries in the filed of Plant Tissue Culture. However most of the research remained of the academic interest and research results were never applied to the field. In many other countries however, the research is more goal oriented and the number of varieties have been released by applying cells and tissue culture techniques," said Ms. Vibha Dhawan of Tata Energy Research Institute. Ms. Dhawan was addressing a conference ‘Tissue Culture in the Industry" at Biotechnology India 2000.

" There was a mushrooming growth in this sector between 1985-1990 and a large number of export oriented units were set up in the country. The technology was brought by the overseas consultants including the mother culture and the product was largely in the European markets. The Industry did not progress as anticipated because of stiff competition from other countries and the non-ability to meet the quality standards" she said.

Till 1997, 2.6 million plants were dispatched from the TERI facilities. The plantlets showed 90-95% survival even in the harsh conditions of the Aravali mountain ranges with out even the life saving irrigation. These demonstrated that once hardened, tissue culture produced plants, are as hardy as seedling raised plants.

Depending on the selection of clone, one can get as much as 200% increase in biomass production as demonstrated in one of the trials of Eucalyptus.

" Clearly through evaluation studies we have reached the stage where the benefits of technology and most commercial plantations will be raised clonally" said Ms. Dhawan.

Commercialisation of Plant Tissue Culture : Dr. Renu Swarup

Plant Tissue Culture is an essential component of Plant Biotechnology. Plant Cell and tissue culture has already contributed significantly to crop improvement and has great potential for the future. Research efforts in plant cell and tissue culture have increased dramatically worldwide in recent years including efforts in developing nations.

In India Tissue Culture research began nearly four decades ago with the first report on production of Haploids through Anther Culture. Tissue culture techniques are now being widely applied for improvement of crop species, forest tree species, horticulture and plantation crop for increased agricultural and forestry production.

Today tissue culture technology is being exploited mainly for large-scale production or micropropagation of elite planting material with desirable characteristics. This technology has now been commercialised globally and has contributed significantly towards the enhanced production of high quality planting material for the export market.

In view of the necessity to perfect this technology not only at lab level but for large scale production, the Department of Biotechnology initiated a major programme on Plant Tissue Culture about a decade ago. A number of Research & Development projects were supported across the country at various laboratories in Universities/Research Institutions. The projects aimed at standardizing/developing protocols for regeneration of important plant species through tissue culture.

Thereafter the thrust of the programme was expanded to include Horticultural and Plantation Crops - Mango, Citrus, Banana, coffee, Tea, Rubber, Spice Crop and Cashew - Research on these crop was supported for tackling specific problems related to production of improved planting material and developing varieties resistant to insects, pests and diseases. So far nearly 150 projects have been supported tackling about 50 major plant species. Protocols have been perfected for nearly 20 species.

India is as country rich in natural resources and its diverse agroclimate zones have the potential to produce a wide variety of agricultural and commercially valuable crops. It has a wide germplasm of rare ornamentals and medicinal species. In general India has many advantages over other countries to meaningfully use the latest biotechnological tools for micropropagation to the maximum.

Managing Biotechnology companies involves directing and controlling the interface between basic research, development, manufacturing and marketing.

A concerted effort in R&D aimed at commercialisation of the products and processes utilizing the existing natural resource of the country would provide economic benefit not only to the resource poor communities, but would also help the nation to compete in the international market. Biotechnology can help India to convert the biological wealth into economic wealth resulting in sustainable development. This would be our aim as we move into the next century.

Day 2 Day 1